{ "_id": "6a23bcec530b9bc726bda008", "Type": "Package", "Package": "RobinCar2", "Title": "ROBust INference for Covariate Adjustment in Randomized Clinical\nTrials", "Version": "0.2.2.9000", "Date": "2026-03-30", "Authors@R": "c(\nperson(\"Liming\", \"Li\", , \"liming.li1@astrazeneca.com\", role = c(\"aut\", \"cre\"), comment = c(ORCID = \"0009-0008-6870-0878\")),\nperson(\"Marlena\", \"Bannick\", , \"mnorwood@uw.edu\", role=\"aut\", comment=c(ORCID=\"0000-0001-6279-5978\")),\nperson(\"Daniel\", \"Sabanes Bove\", , \"daniel@rconis.com\", role = \"aut\", comment = c(ORCID = \"0000-0002-0176-9239\")),\nperson(\"Dong\", \"Xi\", , \"Dong.Xi1@gilead.com\", role = \"aut\"),\nperson(\"Ting\", \"Ye\", , \"tingye1@uw.edu\", role=\"aut\"),\nperson(\"Yanyao\", \"Yi\", , \"yi_yanyao@lilly.com\", role=\"aut\"),\nperson(\"Gregory\", \"Chen\", , \"xiangyi.gregory.chen@msd.com\", role = \"ctb\"),\nperson(\"Gilead Sciences, Inc.\", role = c(\"cph\", \"fnd\")),\nperson(\"F. Hoffmann-La Roche AG\", role = c(\"cph\", \"fnd\")),\nperson(\"Merck Sharp & Dohme, Inc.\", role = c(\"cph\", \"fnd\")),\nperson(\"AstraZeneca plc\", role = c(\"cph\", \"fnd\")),\nperson(\"Eli Lilly and Company\", role = c(\"cph\", \"fnd\")),\nperson(\"Novartis Pharma AG\", role = c(\"cph\", \"fnd\")),\nperson(\"The University of Washington\", role = c(\"cph\", \"fnd\"))\n)", "Description": "Performs robust estimation and inference when using\ncovariate adjustment and/or covariate-adaptive randomization in\nrandomized controlled trials. This package is trimmed to reduce\nthe dependencies and validated to be used across industry. See\n\"FDA's final guidance on covariate\nadjustment\",\nTsiatis (2008) , Bugni et al. (2018)\n, Ye, Shao, Yi, and Zhao\n(2023), Ye, Shao, and Yi\n(2022), Rosenblum and van der Laan\n(2010), Wang et al.\n(2021), Ye, Bannick, Yi, and\nShao (2023), and Bannick,\nShao, Liu, Du, Yi, and Ye\n(2024).", "License": "Apache License 2.0", "URL": "https://github.com/openpharma/RobinCar2/", "BugReports": "https://github.com/openpharma/RobinCar2/issues", "VignetteBuilder": "knitr", "Config/testthat/edition": "3", "Encoding": "UTF-8", "Language": "en-US", "LazyData": "true", "Roxygen": "list(markdown = TRUE)", "RoxygenNote": "7.3.3", "Repository": "https://openpharma.r-universe.dev", "Date/Publication": "2026-04-30 09:12:26 UTC", "RemoteUrl": "https://github.com/openpharma/robincar2", "RemoteRef": "HEAD", "RemoteSha": "b4a5cc40ba9b08b7df88d751e93f04a4da4e8881", "NeedsCompilation": "no", "Packaged": { "Date": "2026-06-06 06:20:40 UTC", "User": "root" }, "Author": "Liming Li [aut, cre] (ORCID: ),\nMarlena Bannick [aut] (ORCID: ),\nDaniel Sabanes Bove [aut] (ORCID:\n),\nDong Xi [aut],\nTing Ye [aut],\nYanyao Yi [aut],\nGregory Chen [ctb],\nGilead Sciences, Inc. [cph, fnd],\nF. Hoffmann-La Roche AG [cph, fnd],\nMerck Sharp & Dohme, Inc. [cph, fnd],\nAstraZeneca plc [cph, fnd],\nEli Lilly and Company [cph, fnd],\nNovartis Pharma AG [cph, fnd],\nThe University of Washington [cph, fnd]", "Maintainer": "Liming Li ", "MD5sum": "d97f9901bec0434c665d58043143d16b", "_user": "openpharma", "_type": "src", "_file": "RobinCar2_0.2.2.9000.tar.gz", "_fileid": "4722c9ddb904ae5778a1543b36c1eaec2141cc85b92fdd48a58c33555453249e", "_filesize": 210913, "_sha256": "4722c9ddb904ae5778a1543b36c1eaec2141cc85b92fdd48a58c33555453249e", "_created": "2026-06-06T06:20:40.000Z", "_published": "2026-06-06T06:23:40.438Z", "_distro": "noble", "_jobs": [ { "job": 79857184083, "time": 151, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "7451943163" }, { "job": 79857184100, "time": 139, "config": "linux-release-x86_64", "r": "4.6.0", "check": "OK", "artifact": "7451941875" }, { "job": 79857184091, "time": 100, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "OK", "artifact": "7451936893" }, { "job": 79857184090, "time": 91, "config": "macos-release-arm64", "r": "4.6.0", "check": "OK", "artifact": "7451935885" }, { "job": 79856355153, "time": 829, "config": "source", "r": "4.6.0", "check": "OK", "artifact": "7451924190" }, { "job": 79857184079, "time": 97, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "7451936790" }, { "job": 79857184113, "time": 122, "config": "windows-devel", "r": "4.7.0", "check": "OK", "artifact": "7451939931" }, { "job": 79857184088, "time": 105, "config": "windows-oldrel", "r": "4.5.3", "check": "OK", "artifact": "7451937631" }, { "job": 79857184098, "time": 137, "config": "windows-release", "r": "4.6.0", "check": "OK", "artifact": "7451941503" } ], "_buildurl": "https://github.com/r-universe/openpharma/actions/runs/27054556329", "_status": "success", "_host": "GitHub-Actions", "_upstream": "https://github.com/openpharma/robincar2", "_commit": { "id": "b4a5cc40ba9b08b7df88d751e93f04a4da4e8881", "author": "Liming <36079400+clarkliming@users.noreply.github.com>", "committer": "GitHub ", "message": "add the biometric bulletin paper (#109)", "time": 1777540346 }, "_maintainer": { "name": "Liming Li", "email": "liming.li1@astrazeneca.com", "login": "clarkliming", "uuid": 36079400 }, "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 3.6", "role": "Depends" }, { "package": "checkmate", "role": "Imports" }, { "package": "numDeriv", "role": "Imports" }, { "package": "MASS", "role": "Imports" }, { "package": "sandwich", "role": "Imports" }, { "package": "stats", "role": "Imports" }, { "package": "survival", "role": "Imports" }, { "package": "utils", "role": "Imports" }, { "package": "knitr", "role": "Suggests" }, { "package": "rmarkdown", "role": "Suggests" }, { "package": "testthat", "version": ">= 3.0", "role": "Suggests" } ], "_owner": "openpharma", "_selfowned": true, "_usedby": 0, "_updates": [ { "week": "2025-28", "n": 1 }, { "week": "2025-33", "n": 2 }, { "week": "2025-35", "n": 1 }, { "week": "2025-37", "n": 4 }, { "week": "2025-39", "n": 1 }, { "week": "2025-44", "n": 1 }, { "week": "2025-45", "n": 1 }, { "week": "2025-46", "n": 1 }, { "week": "2025-48", "n": 2 }, { "week": "2026-02", "n": 2 }, { "week": "2026-03", "n": 1 }, { "week": "2026-14", "n": 1 }, { "week": "2026-18", "n": 1 } ], "_tags": [ { "name": "v0.2.0-rc1", "date": "2025-09-08" }, { "name": "v0.2.0-rc2", "date": "2025-09-09" }, { "name": "v0.2.0", "date": "2025-09-10" }, { "name": "v0.2.1", "date": "2025-09-11" }, { "name": "v0.2.1-rc1", "date": "2025-09-11" }, { "name": "v0.2.2-rc1", "date": "2026-01-08" }, { "name": "v0.2.2-rc2", "date": "2026-01-09" }, { "name": "v0.2.2", "date": "2026-01-12" } ], "_stars": 14, "_contributors": [ { "user": "clarkliming", "count": 27, "uuid": 36079400 }, { "user": "danielinteractive", "count": 13, "uuid": 1071227 }, { "user": "mbannick", "count": 5, "uuid": 23511318 }, { "user": "hoppanda", "count": 2, "uuid": 65814078 }, { "user": "cicdguy", "count": 2, "uuid": 26552821 }, { "user": "xidongdxi", "count": 1, "uuid": 38050865 }, { "user": "gravesti", "count": 1, "uuid": 83659704 } ], "_userbio": { "uuid": 8436743, "type": "organization", "name": "openpharma", "description": "Further precompetitive collaboration in life sciences" }, "_downloads": { "count": 510, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/RobinCar2" }, "_devurl": "https://github.com/openpharma/robincar2", "_searchresults": 9, "_rbuild": "4.6.0", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/NEWS.html", "extra/NEWS.txt", "extra/readme.html", "extra/readme.md", "extra/RobinCar2.html", "manual.pdf" ], "_homeurl": "https://github.com/openpharma/robincar2", "_realowner": "openpharma", "_cranurl": true, "_releases": [ { "version": "0.1.1", "date": "2025-04-03" }, { "version": "0.2.0", "date": "2025-09-09" }, { "version": "0.2.1", "date": "2025-09-11" }, { "version": "0.2.2", "date": "2026-01-09" } ], "_exports": [ "against_ref", "custom_contrast", "eff_jacob", "find_data", "h_diff", "h_jac_diff", "h_jac_log_odds_ratio", "h_jac_log_risk_ratio", "h_jac_odds_ratio", "h_jac_risk_ratio", "h_log_odds_ratio", "h_log_risk_ratio", "h_odds_ratio", "h_risk_ratio", "pairwise", "predict_counterfactual", "robin_glm", "robin_lm", "robin_surv", "table", "treatment_effect", "vcovG", "vcovHC" ], "_datasets": [ { "name": "glm_data", "title": "Example Trial Data for GLMs with Permute-Block Randomization", "object": "glm_data", "class": [ "tbl_df", "tbl", "data.frame" ], "fields": [ "id", "treatment", "s1", "s2", "covar", "y", "y_b" ], "rows": 600, "table": true, "tojson": true }, { "name": "surv_data", "title": "Survival Example Data", "object": "surv_data", "class": [ "data.frame" ], "fields": [ "inst", "time", "status", "age", "sex", "ph.ecog", "ph.karno", "pat.karno", "meal.cal", "wt.loss", "strata", "ecog" ], "rows": 228, "table": true, "tojson": true } ], "_help": [ { "page": "RobinCar2-package", "title": "'RobinCar2' Package", "topics": [ "RobinCar2-package", "RobinCar2" ] }, { "page": "confint", "title": "Confidence Interval", "topics": [ "confint", "confint.prediction_cf", "confint.surv_effect", "confint.treatment_effect" ] }, { "page": "find_data", "title": "Find Data in a Fit", "topics": [ "find_data" ] }, { "page": "glm_data", "title": "Example Trial Data for GLMs with Permute-Block Randomization", "topics": [ "glm_data" ] }, { "page": "contrast", "title": "Contrast Functions and Jacobians", "topics": [ "against_ref", "custom_contrast", "eff_jacob", "h_diff", "h_jac_diff", "h_jac_log_odds_ratio", "h_jac_log_risk_ratio", "h_jac_odds_ratio", "h_jac_risk_ratio", "h_log_odds_ratio", "h_log_risk_ratio", "h_odds_ratio", "h_risk_ratio", "pairwise" ] }, { "page": "predict_counterfactual", "title": "Counterfactual Prediction", "topics": [ "predict_counterfactual" ] }, { "page": "robin_glm", "title": "Covariate adjusted glm model", "topics": [ "robin_glm" ] }, { "page": "robin_lm", "title": "Covariate adjusted lm model", "topics": [ "robin_lm" ] }, { "page": "robin_surv", "title": "Covariate Adjusted and Stratified Survival Analysis", "topics": [ "robin_surv" ] }, { "page": "surv_data", "title": "Survival Example Data", "topics": [ "surv_data" ] }, { "page": "surv_effect_methods", "title": "S3 Methods for 'surv_effect'", "topics": [ "print.surv_effect", "surv_effect_methods", "table", "table.default", "table.surv_effect" ] }, { "page": "treatment_effect", "title": "Treatment Effect", "topics": [ "difference", "log_odds_ratio", "log_risk_ratio", "odds_ratio", "risk_ratio", "treatment_effect" ] }, { "page": "vcovG", "title": "Generalized Covariance (ANHECOVA)", "topics": [ "vcovG" ] }, { "page": "vcovHC", "title": "Heteroskedasticity-consistent covariance matrix for predictions", "topics": [ "vcovHC" ] } ], "_readme": "https://github.com/openpharma/robincar2/raw/HEAD/README.md", "_rundeps": [ "backports", "checkmate", "lattice", "MASS", "Matrix", "numDeriv", "sandwich", "survival", "zoo" ], "_vignettes": [ { "source": "intro.Rmd", "filename": "intro.html", "title": "Package Introduction", "engine": "knitr::rmarkdown", "headings": [ "Common Usage", "Data Introduction", "Obtain Treatment Effect for Continuous Outcomes Using the General Variance", "Obtain Treatment Effect for Binary Outcomes", "Obtain Treatment Effect for Counts", "Using Different Covariate-Adaptive Randomization Schema", "Obtain the Confidence Intervals for the Marginal Means and contrast" ], "created": "2024-05-14 13:46:07", "modified": "2025-10-31 08:24:57", "commits": 6 } ], "_score": 6.737192642704738, "_indexed": true, "_nocasepkg": "robincar2", "_universes": [ "openpharma", "clarkliming" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "0.2.2.9000", "date": "2026-06-06T06:22:52.000Z", "distro": "noble", "commit": "b4a5cc40ba9b08b7df88d751e93f04a4da4e8881", "fileid": "3b7b975fa4c23d91cbb5bb5f7f7146480cf053abf9c31ca829dcb8747baa7fc2", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/openpharma/actions/runs/27054556329" }, { "r": "4.6.0", "os": "linux", "version": "0.2.2.9000", "date": "2026-06-06T06:22:43.000Z", "distro": "noble", "commit": "b4a5cc40ba9b08b7df88d751e93f04a4da4e8881", "fileid": "193c96ae9ba6ab364491d4e23d77fc238da2ce280a93544bf22b43ff9a707839", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/openpharma/actions/runs/27054556329" }, { "r": "4.5.3", "os": "mac", "version": "0.2.2.9000", "date": "2026-06-06T06:22:13.000Z", "commit": "b4a5cc40ba9b08b7df88d751e93f04a4da4e8881", "fileid": "0c0e5a61338da9895bfa1924323fe24f885d5583e486fb362d353ee9685b0e31", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/openpharma/actions/runs/27054556329" }, { "r": "4.6.0", "os": "mac", "version": "0.2.2.9000", "date": "2026-06-06T06:22:05.000Z", "commit": "b4a5cc40ba9b08b7df88d751e93f04a4da4e8881", "fileid": "fa2f5cfd851e76a8de0a4ba49e07ce6cfd8a76d92514e38307ba0ead20d1cdd0", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/openpharma/actions/runs/27054556329" }, { "r": "4.6.0", "os": "wasm", "version": "0.2.2.9000", "date": "2026-06-06T06:22:33.000Z", "commit": "b4a5cc40ba9b08b7df88d751e93f04a4da4e8881", "fileid": "e4391324710de080bd33ea505ab7ae2dc0ee9b7596f467e2cc6650758f45329a", "status": "success", "buildurl": "https://github.com/r-universe/openpharma/actions/runs/27054556329" }, { "r": "4.7.0", "os": "win", "version": "0.2.2.9000", "date": "2026-06-06T06:22:11.000Z", "commit": "b4a5cc40ba9b08b7df88d751e93f04a4da4e8881", "fileid": "99f6ceab89b44c9425c0e23ee49c9946d92dae9df13a35871fd723643243a620", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/openpharma/actions/runs/27054556329" }, { "r": "4.5.3", "os": "win", "version": "0.2.2.9000", "date": "2026-06-06T06:22:01.000Z", "commit": "b4a5cc40ba9b08b7df88d751e93f04a4da4e8881", "fileid": "e34683b6d6661f51f4eefe73241a29aee28b38188b6778e1502d0b3d724175a2", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/openpharma/actions/runs/27054556329" }, { "r": "4.6.0", "os": "win", "version": "0.2.2.9000", "date": "2026-06-06T06:22:20.000Z", "commit": "b4a5cc40ba9b08b7df88d751e93f04a4da4e8881", "fileid": "aad2233dfd3e4717b9f9a9ecd0eebe588c514dad14586d77e5203635b0f66072", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/openpharma/actions/runs/27054556329" } ] }