Package: pmrm
Title: Progression Models for Repeated Measures
Description: A progression model for repeated measures (PMRM) is a
        continuous-time nonlinear mixed-effects model for longitudinal
        clinical trials in progressive diseases. Unlike mixed models
        for repeated measures (MMRMs), which estimate treatment effects
        as linear combinations of additive effects on the outcome
        scale, PMRMs characterize treatment effects in terms of the
        underlying disease trajectory. This framing yields clinically
        interpretable quantities such as average time saved and percent
        reduction in decline due to treatment. This package implements
        frequentist PMRMs by Raket (2022) <doi:10.1002/sim.9581> using
        'RTMB' by Kristensen (2016) <doi:10.18637/jss.v070.i05>.
Version: 0.0.4.9000
License: MIT + file LICENSE
URL: https://github.com/openpharma/pmrm,
        https://openpharma.github.io/pmrm/
BugReports: https://github.com/openpharma/pmrm/issues
Authors@R: c(
  person(
    given = c("William", "Michael"),
    family = "Landau",
    email = "will.landau.oss@gmail.com",
    comment = c(ORCID = "0000-0003-1878-3253"),
    role = c("aut", "cre")
  ),
  person(
    given = c("Lars", "Lau"),
    family = "Raket",
    email = "larslau.raket@lilly.com",
    comment = c(ORCID = "0000-0001-7099-2314"),
    role = "aut"
  ),
  person(
    given = "Kasper",
    family = "Kristensen",
    role = "aut",
    email = "kaskr@dtu.dk",
    comment = c(ORCID="0000-0003-3425-3762")
  ),
  person(
    family = "Eli Lilly and Company",
    role = c("cph", "fnd")
  ))
Depends: R (>= 3.5.0)
Imports: dplyr, generics, ggplot2, Matrix, nlme, RTMB (>= 1.8), rlang,
        stats, tibble, tidyselect, utils, vctrs
Suggests: knitr, markdown, rmarkdown, readr, scales, testthat (>=
        3.0.0)
Encoding: UTF-8
Language: en-US
VignetteBuilder: knitr
Config/testthat/edition: 3
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.3.3
Repository: https://openpharma.r-universe.dev
Date/Publication: 2026-04-03 20:26:51 UTC
RemoteUrl: https://github.com/openpharma/pmrm
RemoteRef: HEAD
RemoteSha: 05b3fd1307dd4fd9693112be2d7ce00e2b1e148f
NeedsCompilation: no
Packaged: 2026-06-02 09:06:50 UTC; root
Author: William Michael Landau [aut, cre] (ORCID:
    <https://orcid.org/0000-0003-1878-3253>),
  Lars Lau Raket [aut] (ORCID: <https://orcid.org/0000-0001-7099-2314>),
  Kasper Kristensen [aut] (ORCID:
    <https://orcid.org/0000-0003-3425-3762>),
  Eli Lilly and Company [cph, fnd]
Maintainer: William Michael Landau <will.landau.oss@gmail.com>