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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "pmrm" in publications use:'
type: software
license: MIT
title: 'pmrm: Progression Models for Repeated Measures'
version: 0.0.4.9000
doi: 10.32614/CRAN.package.pmrm
identifiers:
- type: doi
  value: 10.32614/CRAN.package.pmrm
abstract: A progression model for repeated measures (PMRM) is a continuous-time nonlinear
  mixed-effects model for longitudinal clinical trials in progressive diseases. Unlike
  mixed models for repeated measures (MMRMs), which estimate treatment effects as
  linear combinations of additive effects on the outcome scale, PMRMs characterize
  treatment effects in terms of the underlying disease trajectory. This framing yields
  clinically interpretable quantities such as average time saved and percent reduction
  in decline due to treatment. This package implements frequentist PMRMs by Raket
  (2022) <https://doi.org/10.1002/sim.9581> using 'RTMB' by Kristensen (2016) <https://doi.org/10.18637/jss.v070.i05>.
authors:
- family-names: Landau
  given-names: William Michael
  email: will.landau.oss@gmail.com
  orcid: https://orcid.org/0000-0003-1878-3253
- family-names: Raket
  given-names: Lars Lau
  email: larslau.raket@lilly.com
  orcid: https://orcid.org/0000-0001-7099-2314
- family-names: Kristensen
  given-names: Kasper
  email: kaskr@dtu.dk
  orcid: https://orcid.org/0000-0003-3425-3762
preferred-citation:
  type: generic
  title: Progression Models for Repeated Measures
  authors:
  - family-names: Landau
    given-names: William Michael
    email: will.landau.oss@gmail.com
    orcid: https://orcid.org/0000-0003-1878-3253
  - family-names: Raket
    given-names: Lars Lau
    email: larslau.raket@lilly.com
    orcid: https://orcid.org/0000-0001-7099-2314
  - family-names: Kristensen
    given-names: Kasper
    email: kaskr@dtu.dk
    orcid: https://orcid.org/0000-0003-3425-3762
  year: '2026'
  notes: R package
  doi: 10.32614/CRAN.package.pmrm
  url: https://openpharma.github.io/pmrm/
repository: https://openpharma.r-universe.dev
repository-code: https://github.com/openpharma/pmrm
commit: 05b3fd1307dd4fd9693112be2d7ce00e2b1e148f
url: https://openpharma.github.io/pmrm/
date-released: '2026-04-03'
contact:
- family-names: Landau
  given-names: William Michael
  email: will.landau.oss@gmail.com
  orcid: https://orcid.org/0000-0003-1878-3253
references:
- type: article
  title: 'Progression models for repeated measures: Estimating novel treatment effects
    in progressive diseases'
  authors:
  - family-names: Raket
    given-names: Lars Lau
    email: larslau.raket@lilly.com
    orcid: https://orcid.org/0000-0001-7099-2314
  journal: Statistics in Medicine
  year: '2022'
  volume: '41'
  issue: '28'
  doi: 10.1002/sim.9581
  url: https://doi.org/10.1002/sim.9581
  start: 5537-5557