mmrm - Mixed Models for Repeated Measures

Mixed models for repeated measures (MMRM) are a popular choice for analyzing longitudinal continuous outcomes in randomized clinical trials and beyond; see Cnaan, Laird and Slasor (1997) <doi:10.1002/(SICI)1097-0258(19971030)16:20%3C2349::AID-SIM667%3E3.0.CO;2-E> for a tutorial and Mallinckrodt, Lane, Schnell, Peng and Mancuso (2008) <doi:10.1177/009286150804200402> for a review. This package implements MMRM based on the marginal linear model without random effects using Template Model Builder ('TMB') which enables fast and robust model fitting. Users can specify a variety of covariance matrices, weight observations, fit models with restricted or standard maximum likelihood inference, perform hypothesis testing with Satterthwaite or Kenward-Roger adjustment, and extract least square means estimates by using 'emmeans'.

Last updated 1 months ago

12.34 score 132 stars 4 packages 112 scripts 3.6k downloads

DoseFinding - Planning and Analyzing Dose Finding Experiments

The DoseFinding package provides functions for the design and analysis of dose-finding experiments (with focus on pharmaceutical Phase II clinical trials). It provides functions for: multiple contrast tests, fitting non-linear dose-response models (using Bayesian and non-Bayesian estimation), calculating optimal designs and an implementation of the MCPMod methodology (Pinheiro et al. (2014) <doi:10.1002/sim.6052>).

Last updated 3 months ago

9.33 score 2 stars 10 packages 93 scripts 1.6k downloads

brms.mmrm - Bayesian MMRMs using 'brms'

The mixed model for repeated measures (MMRM) is a popular model for longitudinal clinical trial data with continuous endpoints, and 'brms' is a powerful and versatile package for fitting Bayesian regression models. The 'brms.mmrm' R package leverages 'brms' to run MMRMs, and it supports a simplified interfaced to reduce difficulty and align with the best practices of the life sciences. References: Bürkner (2017) <doi:10.18637/jss.v080.i01>, Mallinckrodt (2008) <doi:10.1177/009286150804200402>.

Last updated 2 months ago

brmslife-sciencesmc-stanmmrmstanstatistics

8.84 score 18 stars 13 scripts 752 downloads

crmPack - Object-Oriented Implementation of CRM Designs

Implements a wide range of model-based dose escalation designs, ranging from classical and modern continual reassessment methods (CRMs) based on dose-limiting toxicity endpoints to dual-endpoint designs taking into account a biomarker/efficacy outcome. The focus is on Bayesian inference, making it very easy to setup a new design with its own JAGS code. However, it is also possible to implement 3+3 designs for comparison or models with non-Bayesian estimation. The whole package is written in a modular form in the S4 class system, making it very flexible for adaptation to new models, escalation or stopping rules. Further details are presented in Sabanes Bove et al. (2019) <doi:10.18637/jss.v089.i10>.

Last updated 1 months ago

7.94 score 20 stars 208 scripts 446 downloads

graphicalMCP - Graphical Multiple Comparison Procedures

Multiple comparison procedures (MCPs) control the familywise error rate in clinical trials. Graphical MCPs include many commonly used procedures as special cases; see Bretz et al. (2011) <doi:10.1002/bimj.201000239>, Lu (2016) <doi:10.1002/sim.6985>, and Xi et al. (2017) <doi:10.1002/bimj.201600233>. This package is a low-dependency implementation of graphical MCPs which allow mixed types of tests. It also includes power simulations and visualization of graphical MCPs.

Last updated 13 days ago

7.37 score 13 stars 17 scripts 145 downloads

savvyr - Survival Analysis for AdVerse Events with VarYing Follow-Up Times

The SAVVY (Survival Analysis for AdVerse Events with VarYing Follow-Up Times) project is a consortium of academic and pharmaceutical industry partners that aims to improve the analyses of adverse event (AE) data in clinical trials through the use of survival techniques appropriately dealing with varying follow-up times and competing events, see Stegherr, Schmoor, Beyersmann, et al. (2021) <doi:10.1186/s13063-021-05354-x>. Although statistical methodologies have advanced, in AE analyses often the incidence proportion, the incidence density or a non-parametric Kaplan-Meier estimator are used, which either ignore censoring or competing events. This package contains functions to easily conduct the proposed improved AE analyses.

Last updated 6 months ago

5.60 score 4 stars 1 scripts 132 downloads

beeca - Binary Endpoint Estimation with Covariate Adjustment

Performs estimation of marginal treatment effects for binary outcomes when using logistic regression working models with covariate adjustment (see discussions in Magirr et al (2024) <https://osf.io/9mp58/>). Implements the variance estimators of Ge et al (2011) <doi:10.1177/009286151104500409> and Ye et al (2023) <doi:10.1080/24754269.2023.2205802>.

Last updated 10 days ago

5.30 score 4 stars 5 scripts 517 downloads

simaerep - Find Clinical Trial Sites Under-Reporting Adverse Events

Monitoring of Adverse Event (AE) reporting in clinical trials is important for patient safety. Sites that are under-reporting AEs can be detected using Bootstrap-based simulations that simulate overall AE reporting. Based on the simulation an AE under-reporting probability is assigned to each site in a given trial (Koneswarakantha 2021 <doi:10.1007/s40264-020-01011-5>).

Last updated 2 months ago

ae-reportingclinical-trials

5.20 score 21 stars 25 scripts 475 downloads

elaborator - A 'shiny' Application for Exploring Laboratory Data

A novel concept for generating knowledge and gaining insights into laboratory data. You will be able to efficiently and easily explore your laboratory data from different perspectives. Janitza, S., Majumder, M., Mendolia, F., Jeske, S., & Kulmann, H. (2021) <doi:10.1007/s43441-021-00318-4>.

Last updated 2 months ago

4.48 score 5 stars 202 downloads

roxytypes - Typed Parameter Tags for Integration with 'roxygen2'

Provides typed parameter documentation tags for integration with 'roxygen2'. Typed parameter tags provide a consistent interface for annotating expected types for parameters and returned values. Tools for converting from existing styles are also provided to easily adapt projects which implement typed documentation by convention rather than tag. Use the default format or provide your own.

Last updated 1 months ago

roxygen2type-hints

4.00 score 5 stars 1 scripts 321 downloads

roxylint - Lint 'roxygen2'-Generated Documentation

Provides formatting linting to 'roxygen2' tags. Linters report 'roxygen2' tags that do not conform to a standard style. These linters can be a helpful check for building more consistent documentation and to provide reminders about best practices or checks for typos. Default linting suites are provided for common style guides such as the one followed by the 'tidyverse', though custom linters can be registered by other packages or be custom-tailored to a specific package.

Last updated 9 months ago

linterroxygen2

3.93 score 17 stars 164 downloads

mtdesign - Mander and Thompson Designs

Implements Mander & Thompson's (2010) <doi:10.1016/j.cct.2010.07.008> methods for two-stage designs optimal under the alternative hypothesis for phase II [cancer] trials. Also provides an implementation of Simon's (1989) <doi:10.1016/0197-2456(89)90015-9> original methodology and allows exploration of the operating characteristics of sub-optimal designs.

Last updated 17 days ago

3.78 score 3 stars 4 scripts 136 downloads